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rabbit anti cd86 antibody  (Cell Signaling Technology Inc)
86
Cell Signaling Technology Inc rabbit anti cd86 antibody
Circadian disruption promotes inflammation, lipid accumulation, and fibrosis in MASH mice (A) The relative mRNA expression of lipid-metabolism-related genes ( Srebp , Fasn , and Acaca ), inflammation-related genes ( Cxcl2 , Ccl2 , and Nos2 ), and fibrosis-related genes ( Col3a1 , Col4a1 , and α-Sma ) in MASH with or without circadian disruption, n = 6. (B) Flow cytometry analysis of the abundance of macrophages (CD11b + F4/80 + ), M1 cells <t>(CD86</t> + CD206 − ), and M2 cells (CD86 − CD206 + ) in the liver in each group, n = 6. (C) Comparison of M1/M2 polarization in the liver in each group by CD86/CD206 detected by immunohistochemistry. Scale bars: 100 μm (10×). (D) Serum IL-6, IL-1β, and TNF-α in each group, n = 6. (E) The relative expression level of the oxidative stress indicator ROS, the content of GSH, and the relative mRNA expression level of Hif-1α related to them in each group, n = 6. (F) The total number of genes detected by liver transcriptomics, as well as the number of genes that are relatively upregulated and downregulated in the two groups. (G) NMDS plot of the main components of liver transcriptomics in each group, n = 4. (H) Reactome analysis results (barplot) of liver transcriptomics in the two groups. (I) Reactome analysis results (dotplot) of liver transcriptomics in the two groups. Data are expressed as mean ± SD ( n = 4–6), ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001, compared with the MASH group. p values were calculated using unpaired t test. Srebp , sterol regulatory element-binding protein; Fasn , fatty acid synthase; Acaca , acetyl-CoA carboxylase; Cxcl2 , chemokine (C–X–C motif) ligand 2; Ccl2 , chemokine (C–C motif) ligand 2; Nos2 , nitric oxide synthase 2; Col3a1 , collagen alpha-1 (III) chain; Col4a1 , collagen alpha-1 (IV) chain; α-Sma , α-smooth muscle actin; M1, M1 polarization of macrophages; M2, M2 polarization of macrophages; CD11b, marker of mouse macrophages; F4/80, marker of mouse macrophages; CD86, marker of M1 polarization of mouse macrophages; CD206, marker of M2 polarization of mouse macrophages; IL-6, interleukin-6; IL-1β, interleukin-1 beta; TNF-α, tumor necrosis factor-alpha; ROS, reactive oxygen species; GSH, glutathione; Hif-1α , hypoxia inducible factor-1 alpha; NMDS, non-metric multidimensional scaling.
Rabbit Anti Cd86 Antibody, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rabbit anti cd86 antibody/product/Cell Signaling Technology Inc
Average 86 stars, based on 1 article reviews
rabbit anti cd86 antibody - by Bioz Stars, 2026-05
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cst 91882  (Cell Signaling Technology Inc)
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Cell Signaling Technology Inc cst 91882
Circadian disruption promotes inflammation, lipid accumulation, and fibrosis in MASH mice (A) The relative mRNA expression of lipid-metabolism-related genes ( Srebp , Fasn , and Acaca ), inflammation-related genes ( Cxcl2 , Ccl2 , and Nos2 ), and fibrosis-related genes ( Col3a1 , Col4a1 , and α-Sma ) in MASH with or without circadian disruption, n = 6. (B) Flow cytometry analysis of the abundance of macrophages (CD11b + F4/80 + ), M1 cells <t>(CD86</t> + CD206 − ), and M2 cells (CD86 − CD206 + ) in the liver in each group, n = 6. (C) Comparison of M1/M2 polarization in the liver in each group by CD86/CD206 detected by immunohistochemistry. Scale bars: 100 μm (10×). (D) Serum IL-6, IL-1β, and TNF-α in each group, n = 6. (E) The relative expression level of the oxidative stress indicator ROS, the content of GSH, and the relative mRNA expression level of Hif-1α related to them in each group, n = 6. (F) The total number of genes detected by liver transcriptomics, as well as the number of genes that are relatively upregulated and downregulated in the two groups. (G) NMDS plot of the main components of liver transcriptomics in each group, n = 4. (H) Reactome analysis results (barplot) of liver transcriptomics in the two groups. (I) Reactome analysis results (dotplot) of liver transcriptomics in the two groups. Data are expressed as mean ± SD ( n = 4–6), ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001, compared with the MASH group. p values were calculated using unpaired t test. Srebp , sterol regulatory element-binding protein; Fasn , fatty acid synthase; Acaca , acetyl-CoA carboxylase; Cxcl2 , chemokine (C–X–C motif) ligand 2; Ccl2 , chemokine (C–C motif) ligand 2; Nos2 , nitric oxide synthase 2; Col3a1 , collagen alpha-1 (III) chain; Col4a1 , collagen alpha-1 (IV) chain; α-Sma , α-smooth muscle actin; M1, M1 polarization of macrophages; M2, M2 polarization of macrophages; CD11b, marker of mouse macrophages; F4/80, marker of mouse macrophages; CD86, marker of M1 polarization of mouse macrophages; CD206, marker of M2 polarization of mouse macrophages; IL-6, interleukin-6; IL-1β, interleukin-1 beta; TNF-α, tumor necrosis factor-alpha; ROS, reactive oxygen species; GSH, glutathione; Hif-1α , hypoxia inducible factor-1 alpha; NMDS, non-metric multidimensional scaling.
Cst 91882, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 96 stars, based on 1 article reviews
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cd86 rabbit mab  (Cell Signaling Technology Inc)
86
Cell Signaling Technology Inc cd86 rabbit mab
Circadian disruption promotes inflammation, lipid accumulation, and fibrosis in MASH mice (A) The relative mRNA expression of lipid-metabolism-related genes ( Srebp , Fasn , and Acaca ), inflammation-related genes ( Cxcl2 , Ccl2 , and Nos2 ), and fibrosis-related genes ( Col3a1 , Col4a1 , and α-Sma ) in MASH with or without circadian disruption, n = 6. (B) Flow cytometry analysis of the abundance of macrophages (CD11b + F4/80 + ), M1 cells <t>(CD86</t> + CD206 − ), and M2 cells (CD86 − CD206 + ) in the liver in each group, n = 6. (C) Comparison of M1/M2 polarization in the liver in each group by CD86/CD206 detected by immunohistochemistry. Scale bars: 100 μm (10×). (D) Serum IL-6, IL-1β, and TNF-α in each group, n = 6. (E) The relative expression level of the oxidative stress indicator ROS, the content of GSH, and the relative mRNA expression level of Hif-1α related to them in each group, n = 6. (F) The total number of genes detected by liver transcriptomics, as well as the number of genes that are relatively upregulated and downregulated in the two groups. (G) NMDS plot of the main components of liver transcriptomics in each group, n = 4. (H) Reactome analysis results (barplot) of liver transcriptomics in the two groups. (I) Reactome analysis results (dotplot) of liver transcriptomics in the two groups. Data are expressed as mean ± SD ( n = 4–6), ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001, compared with the MASH group. p values were calculated using unpaired t test. Srebp , sterol regulatory element-binding protein; Fasn , fatty acid synthase; Acaca , acetyl-CoA carboxylase; Cxcl2 , chemokine (C–X–C motif) ligand 2; Ccl2 , chemokine (C–C motif) ligand 2; Nos2 , nitric oxide synthase 2; Col3a1 , collagen alpha-1 (III) chain; Col4a1 , collagen alpha-1 (IV) chain; α-Sma , α-smooth muscle actin; M1, M1 polarization of macrophages; M2, M2 polarization of macrophages; CD11b, marker of mouse macrophages; F4/80, marker of mouse macrophages; CD86, marker of M1 polarization of mouse macrophages; CD206, marker of M2 polarization of mouse macrophages; IL-6, interleukin-6; IL-1β, interleukin-1 beta; TNF-α, tumor necrosis factor-alpha; ROS, reactive oxygen species; GSH, glutathione; Hif-1α , hypoxia inducible factor-1 alpha; NMDS, non-metric multidimensional scaling.
Cd86 Rabbit Mab, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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rabbit anti cd86 polyclonal antibody  (Elabscience Biotechnology)
94
Elabscience Biotechnology rabbit anti cd86 polyclonal antibody
Circadian disruption promotes inflammation, lipid accumulation, and fibrosis in MASH mice (A) The relative mRNA expression of lipid-metabolism-related genes ( Srebp , Fasn , and Acaca ), inflammation-related genes ( Cxcl2 , Ccl2 , and Nos2 ), and fibrosis-related genes ( Col3a1 , Col4a1 , and α-Sma ) in MASH with or without circadian disruption, n = 6. (B) Flow cytometry analysis of the abundance of macrophages (CD11b + F4/80 + ), M1 cells <t>(CD86</t> + CD206 − ), and M2 cells (CD86 − CD206 + ) in the liver in each group, n = 6. (C) Comparison of M1/M2 polarization in the liver in each group by CD86/CD206 detected by immunohistochemistry. Scale bars: 100 μm (10×). (D) Serum IL-6, IL-1β, and TNF-α in each group, n = 6. (E) The relative expression level of the oxidative stress indicator ROS, the content of GSH, and the relative mRNA expression level of Hif-1α related to them in each group, n = 6. (F) The total number of genes detected by liver transcriptomics, as well as the number of genes that are relatively upregulated and downregulated in the two groups. (G) NMDS plot of the main components of liver transcriptomics in each group, n = 4. (H) Reactome analysis results (barplot) of liver transcriptomics in the two groups. (I) Reactome analysis results (dotplot) of liver transcriptomics in the two groups. Data are expressed as mean ± SD ( n = 4–6), ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001, compared with the MASH group. p values were calculated using unpaired t test. Srebp , sterol regulatory element-binding protein; Fasn , fatty acid synthase; Acaca , acetyl-CoA carboxylase; Cxcl2 , chemokine (C–X–C motif) ligand 2; Ccl2 , chemokine (C–C motif) ligand 2; Nos2 , nitric oxide synthase 2; Col3a1 , collagen alpha-1 (III) chain; Col4a1 , collagen alpha-1 (IV) chain; α-Sma , α-smooth muscle actin; M1, M1 polarization of macrophages; M2, M2 polarization of macrophages; CD11b, marker of mouse macrophages; F4/80, marker of mouse macrophages; CD86, marker of M1 polarization of mouse macrophages; CD206, marker of M2 polarization of mouse macrophages; IL-6, interleukin-6; IL-1β, interleukin-1 beta; TNF-α, tumor necrosis factor-alpha; ROS, reactive oxygen species; GSH, glutathione; Hif-1α , hypoxia inducible factor-1 alpha; NMDS, non-metric multidimensional scaling.
Rabbit Anti Cd86 Polyclonal Antibody, supplied by Elabscience Biotechnology, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rabbit anti cd86 polyclonal antibody/product/Elabscience Biotechnology
Average 94 stars, based on 1 article reviews
rabbit anti cd86 polyclonal antibody - by Bioz Stars, 2026-05
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rabbit  (Boster Bio)
99
Boster Bio rabbit
Circadian disruption promotes inflammation, lipid accumulation, and fibrosis in MASH mice (A) The relative mRNA expression of lipid-metabolism-related genes ( Srebp , Fasn , and Acaca ), inflammation-related genes ( Cxcl2 , Ccl2 , and Nos2 ), and fibrosis-related genes ( Col3a1 , Col4a1 , and α-Sma ) in MASH with or without circadian disruption, n = 6. (B) Flow cytometry analysis of the abundance of macrophages (CD11b + F4/80 + ), M1 cells <t>(CD86</t> + CD206 − ), and M2 cells (CD86 − CD206 + ) in the liver in each group, n = 6. (C) Comparison of M1/M2 polarization in the liver in each group by CD86/CD206 detected by immunohistochemistry. Scale bars: 100 μm (10×). (D) Serum IL-6, IL-1β, and TNF-α in each group, n = 6. (E) The relative expression level of the oxidative stress indicator ROS, the content of GSH, and the relative mRNA expression level of Hif-1α related to them in each group, n = 6. (F) The total number of genes detected by liver transcriptomics, as well as the number of genes that are relatively upregulated and downregulated in the two groups. (G) NMDS plot of the main components of liver transcriptomics in each group, n = 4. (H) Reactome analysis results (barplot) of liver transcriptomics in the two groups. (I) Reactome analysis results (dotplot) of liver transcriptomics in the two groups. Data are expressed as mean ± SD ( n = 4–6), ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001, compared with the MASH group. p values were calculated using unpaired t test. Srebp , sterol regulatory element-binding protein; Fasn , fatty acid synthase; Acaca , acetyl-CoA carboxylase; Cxcl2 , chemokine (C–X–C motif) ligand 2; Ccl2 , chemokine (C–C motif) ligand 2; Nos2 , nitric oxide synthase 2; Col3a1 , collagen alpha-1 (III) chain; Col4a1 , collagen alpha-1 (IV) chain; α-Sma , α-smooth muscle actin; M1, M1 polarization of macrophages; M2, M2 polarization of macrophages; CD11b, marker of mouse macrophages; F4/80, marker of mouse macrophages; CD86, marker of M1 polarization of mouse macrophages; CD206, marker of M2 polarization of mouse macrophages; IL-6, interleukin-6; IL-1β, interleukin-1 beta; TNF-α, tumor necrosis factor-alpha; ROS, reactive oxygen species; GSH, glutathione; Hif-1α , hypoxia inducible factor-1 alpha; NMDS, non-metric multidimensional scaling.
Rabbit, supplied by Boster Bio, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rabbit/product/Boster Bio
Average 99 stars, based on 1 article reviews
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anti cd86  (Cell Signaling Technology Inc)
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Cell Signaling Technology Inc anti cd86
Circadian disruption promotes inflammation, lipid accumulation, and fibrosis in MASH mice (A) The relative mRNA expression of lipid-metabolism-related genes ( Srebp , Fasn , and Acaca ), inflammation-related genes ( Cxcl2 , Ccl2 , and Nos2 ), and fibrosis-related genes ( Col3a1 , Col4a1 , and α-Sma ) in MASH with or without circadian disruption, n = 6. (B) Flow cytometry analysis of the abundance of macrophages (CD11b + F4/80 + ), M1 cells <t>(CD86</t> + CD206 − ), and M2 cells (CD86 − CD206 + ) in the liver in each group, n = 6. (C) Comparison of M1/M2 polarization in the liver in each group by CD86/CD206 detected by immunohistochemistry. Scale bars: 100 μm (10×). (D) Serum IL-6, IL-1β, and TNF-α in each group, n = 6. (E) The relative expression level of the oxidative stress indicator ROS, the content of GSH, and the relative mRNA expression level of Hif-1α related to them in each group, n = 6. (F) The total number of genes detected by liver transcriptomics, as well as the number of genes that are relatively upregulated and downregulated in the two groups. (G) NMDS plot of the main components of liver transcriptomics in each group, n = 4. (H) Reactome analysis results (barplot) of liver transcriptomics in the two groups. (I) Reactome analysis results (dotplot) of liver transcriptomics in the two groups. Data are expressed as mean ± SD ( n = 4–6), ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001, compared with the MASH group. p values were calculated using unpaired t test. Srebp , sterol regulatory element-binding protein; Fasn , fatty acid synthase; Acaca , acetyl-CoA carboxylase; Cxcl2 , chemokine (C–X–C motif) ligand 2; Ccl2 , chemokine (C–C motif) ligand 2; Nos2 , nitric oxide synthase 2; Col3a1 , collagen alpha-1 (III) chain; Col4a1 , collagen alpha-1 (IV) chain; α-Sma , α-smooth muscle actin; M1, M1 polarization of macrophages; M2, M2 polarization of macrophages; CD11b, marker of mouse macrophages; F4/80, marker of mouse macrophages; CD86, marker of M1 polarization of mouse macrophages; CD206, marker of M2 polarization of mouse macrophages; IL-6, interleukin-6; IL-1β, interleukin-1 beta; TNF-α, tumor necrosis factor-alpha; ROS, reactive oxygen species; GSH, glutathione; Hif-1α , hypoxia inducible factor-1 alpha; NMDS, non-metric multidimensional scaling.
Anti Cd86, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/anti cd86/product/Cell Signaling Technology Inc
Average 97 stars, based on 1 article reviews
anti cd86 - by Bioz Stars, 2026-05
97/100 stars
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rabbit anti cd86  (Cell Signaling Technology Inc)
86
Cell Signaling Technology Inc rabbit anti cd86
Circadian disruption promotes inflammation, lipid accumulation, and fibrosis in MASH mice (A) The relative mRNA expression of lipid-metabolism-related genes ( Srebp , Fasn , and Acaca ), inflammation-related genes ( Cxcl2 , Ccl2 , and Nos2 ), and fibrosis-related genes ( Col3a1 , Col4a1 , and α-Sma ) in MASH with or without circadian disruption, n = 6. (B) Flow cytometry analysis of the abundance of macrophages (CD11b + F4/80 + ), M1 cells <t>(CD86</t> + CD206 − ), and M2 cells (CD86 − CD206 + ) in the liver in each group, n = 6. (C) Comparison of M1/M2 polarization in the liver in each group by CD86/CD206 detected by immunohistochemistry. Scale bars: 100 μm (10×). (D) Serum IL-6, IL-1β, and TNF-α in each group, n = 6. (E) The relative expression level of the oxidative stress indicator ROS, the content of GSH, and the relative mRNA expression level of Hif-1α related to them in each group, n = 6. (F) The total number of genes detected by liver transcriptomics, as well as the number of genes that are relatively upregulated and downregulated in the two groups. (G) NMDS plot of the main components of liver transcriptomics in each group, n = 4. (H) Reactome analysis results (barplot) of liver transcriptomics in the two groups. (I) Reactome analysis results (dotplot) of liver transcriptomics in the two groups. Data are expressed as mean ± SD ( n = 4–6), ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001, compared with the MASH group. p values were calculated using unpaired t test. Srebp , sterol regulatory element-binding protein; Fasn , fatty acid synthase; Acaca , acetyl-CoA carboxylase; Cxcl2 , chemokine (C–X–C motif) ligand 2; Ccl2 , chemokine (C–C motif) ligand 2; Nos2 , nitric oxide synthase 2; Col3a1 , collagen alpha-1 (III) chain; Col4a1 , collagen alpha-1 (IV) chain; α-Sma , α-smooth muscle actin; M1, M1 polarization of macrophages; M2, M2 polarization of macrophages; CD11b, marker of mouse macrophages; F4/80, marker of mouse macrophages; CD86, marker of M1 polarization of mouse macrophages; CD206, marker of M2 polarization of mouse macrophages; IL-6, interleukin-6; IL-1β, interleukin-1 beta; TNF-α, tumor necrosis factor-alpha; ROS, reactive oxygen species; GSH, glutathione; Hif-1α , hypoxia inducible factor-1 alpha; NMDS, non-metric multidimensional scaling.
Rabbit Anti Cd86, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rabbit anti cd86/product/Cell Signaling Technology Inc
Average 86 stars, based on 1 article reviews
rabbit anti cd86 - by Bioz Stars, 2026-05
86/100 stars
  Buy from Supplier
anti cd86 rabbit monoclonal antibody  (Cell Signaling Technology Inc)
94
Cell Signaling Technology Inc anti cd86 rabbit monoclonal antibody
Circadian disruption promotes inflammation, lipid accumulation, and fibrosis in MASH mice (A) The relative mRNA expression of lipid-metabolism-related genes ( Srebp , Fasn , and Acaca ), inflammation-related genes ( Cxcl2 , Ccl2 , and Nos2 ), and fibrosis-related genes ( Col3a1 , Col4a1 , and α-Sma ) in MASH with or without circadian disruption, n = 6. (B) Flow cytometry analysis of the abundance of macrophages (CD11b + F4/80 + ), M1 cells <t>(CD86</t> + CD206 − ), and M2 cells (CD86 − CD206 + ) in the liver in each group, n = 6. (C) Comparison of M1/M2 polarization in the liver in each group by CD86/CD206 detected by immunohistochemistry. Scale bars: 100 μm (10×). (D) Serum IL-6, IL-1β, and TNF-α in each group, n = 6. (E) The relative expression level of the oxidative stress indicator ROS, the content of GSH, and the relative mRNA expression level of Hif-1α related to them in each group, n = 6. (F) The total number of genes detected by liver transcriptomics, as well as the number of genes that are relatively upregulated and downregulated in the two groups. (G) NMDS plot of the main components of liver transcriptomics in each group, n = 4. (H) Reactome analysis results (barplot) of liver transcriptomics in the two groups. (I) Reactome analysis results (dotplot) of liver transcriptomics in the two groups. Data are expressed as mean ± SD ( n = 4–6), ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001, compared with the MASH group. p values were calculated using unpaired t test. Srebp , sterol regulatory element-binding protein; Fasn , fatty acid synthase; Acaca , acetyl-CoA carboxylase; Cxcl2 , chemokine (C–X–C motif) ligand 2; Ccl2 , chemokine (C–C motif) ligand 2; Nos2 , nitric oxide synthase 2; Col3a1 , collagen alpha-1 (III) chain; Col4a1 , collagen alpha-1 (IV) chain; α-Sma , α-smooth muscle actin; M1, M1 polarization of macrophages; M2, M2 polarization of macrophages; CD11b, marker of mouse macrophages; F4/80, marker of mouse macrophages; CD86, marker of M1 polarization of mouse macrophages; CD206, marker of M2 polarization of mouse macrophages; IL-6, interleukin-6; IL-1β, interleukin-1 beta; TNF-α, tumor necrosis factor-alpha; ROS, reactive oxygen species; GSH, glutathione; Hif-1α , hypoxia inducible factor-1 alpha; NMDS, non-metric multidimensional scaling.
Anti Cd86 Rabbit Monoclonal Antibody, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/anti cd86 rabbit monoclonal antibody/product/Cell Signaling Technology Inc
Average 94 stars, based on 1 article reviews
anti cd86 rabbit monoclonal antibody - by Bioz Stars, 2026-05
94/100 stars
  Buy from Supplier

Image Search Results


Circadian disruption promotes inflammation, lipid accumulation, and fibrosis in MASH mice (A) The relative mRNA expression of lipid-metabolism-related genes ( Srebp , Fasn , and Acaca ), inflammation-related genes ( Cxcl2 , Ccl2 , and Nos2 ), and fibrosis-related genes ( Col3a1 , Col4a1 , and α-Sma ) in MASH with or without circadian disruption, n = 6. (B) Flow cytometry analysis of the abundance of macrophages (CD11b + F4/80 + ), M1 cells (CD86 + CD206 − ), and M2 cells (CD86 − CD206 + ) in the liver in each group, n = 6. (C) Comparison of M1/M2 polarization in the liver in each group by CD86/CD206 detected by immunohistochemistry. Scale bars: 100 μm (10×). (D) Serum IL-6, IL-1β, and TNF-α in each group, n = 6. (E) The relative expression level of the oxidative stress indicator ROS, the content of GSH, and the relative mRNA expression level of Hif-1α related to them in each group, n = 6. (F) The total number of genes detected by liver transcriptomics, as well as the number of genes that are relatively upregulated and downregulated in the two groups. (G) NMDS plot of the main components of liver transcriptomics in each group, n = 4. (H) Reactome analysis results (barplot) of liver transcriptomics in the two groups. (I) Reactome analysis results (dotplot) of liver transcriptomics in the two groups. Data are expressed as mean ± SD ( n = 4–6), ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001, compared with the MASH group. p values were calculated using unpaired t test. Srebp , sterol regulatory element-binding protein; Fasn , fatty acid synthase; Acaca , acetyl-CoA carboxylase; Cxcl2 , chemokine (C–X–C motif) ligand 2; Ccl2 , chemokine (C–C motif) ligand 2; Nos2 , nitric oxide synthase 2; Col3a1 , collagen alpha-1 (III) chain; Col4a1 , collagen alpha-1 (IV) chain; α-Sma , α-smooth muscle actin; M1, M1 polarization of macrophages; M2, M2 polarization of macrophages; CD11b, marker of mouse macrophages; F4/80, marker of mouse macrophages; CD86, marker of M1 polarization of mouse macrophages; CD206, marker of M2 polarization of mouse macrophages; IL-6, interleukin-6; IL-1β, interleukin-1 beta; TNF-α, tumor necrosis factor-alpha; ROS, reactive oxygen species; GSH, glutathione; Hif-1α , hypoxia inducible factor-1 alpha; NMDS, non-metric multidimensional scaling.

Journal: iScience

Article Title: Circadian disruption exacerbates MASH by reducing Akkermansia muciniphila via the FXR-CYP7A1-bile acid axis

doi: 10.1016/j.isci.2026.115397

Figure Lengend Snippet: Circadian disruption promotes inflammation, lipid accumulation, and fibrosis in MASH mice (A) The relative mRNA expression of lipid-metabolism-related genes ( Srebp , Fasn , and Acaca ), inflammation-related genes ( Cxcl2 , Ccl2 , and Nos2 ), and fibrosis-related genes ( Col3a1 , Col4a1 , and α-Sma ) in MASH with or without circadian disruption, n = 6. (B) Flow cytometry analysis of the abundance of macrophages (CD11b + F4/80 + ), M1 cells (CD86 + CD206 − ), and M2 cells (CD86 − CD206 + ) in the liver in each group, n = 6. (C) Comparison of M1/M2 polarization in the liver in each group by CD86/CD206 detected by immunohistochemistry. Scale bars: 100 μm (10×). (D) Serum IL-6, IL-1β, and TNF-α in each group, n = 6. (E) The relative expression level of the oxidative stress indicator ROS, the content of GSH, and the relative mRNA expression level of Hif-1α related to them in each group, n = 6. (F) The total number of genes detected by liver transcriptomics, as well as the number of genes that are relatively upregulated and downregulated in the two groups. (G) NMDS plot of the main components of liver transcriptomics in each group, n = 4. (H) Reactome analysis results (barplot) of liver transcriptomics in the two groups. (I) Reactome analysis results (dotplot) of liver transcriptomics in the two groups. Data are expressed as mean ± SD ( n = 4–6), ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001, compared with the MASH group. p values were calculated using unpaired t test. Srebp , sterol regulatory element-binding protein; Fasn , fatty acid synthase; Acaca , acetyl-CoA carboxylase; Cxcl2 , chemokine (C–X–C motif) ligand 2; Ccl2 , chemokine (C–C motif) ligand 2; Nos2 , nitric oxide synthase 2; Col3a1 , collagen alpha-1 (III) chain; Col4a1 , collagen alpha-1 (IV) chain; α-Sma , α-smooth muscle actin; M1, M1 polarization of macrophages; M2, M2 polarization of macrophages; CD11b, marker of mouse macrophages; F4/80, marker of mouse macrophages; CD86, marker of M1 polarization of mouse macrophages; CD206, marker of M2 polarization of mouse macrophages; IL-6, interleukin-6; IL-1β, interleukin-1 beta; TNF-α, tumor necrosis factor-alpha; ROS, reactive oxygen species; GSH, glutathione; Hif-1α , hypoxia inducible factor-1 alpha; NMDS, non-metric multidimensional scaling.

Article Snippet: Rabbit anti-CD86 antibody , Cell Signaling Technology , Cat# 91882; RRID: AB_2797422.

Techniques: Disruption, Expressing, Flow Cytometry, Comparison, Immunohistochemistry, Transcriptomics, Binding Assay, Marker